| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10953940 | Journal of Molecular and Cellular Cardiology | 2011 | 8 Pages |
Abstract
⺠Isoform changes in myofilament proteins induce changes in cardiac metabolic phenotype. ⺠Expression of the ssTnI, in place of adult cTnI, induces metabolic protection to ischemic stress. ⺠Adult mouse hearts expressing ssTnI exhibit augmented glycolytic ATP production during ischemia. ⺠Expression of fetal ssTnI induces resistance to hypoxia, due to ischemia, similar to fetal hearts.
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Authors
Kayla M. Pound, Grace M. Arteaga, Mathew Fasano, Tanganyika Wilder, Susan K. Fischer, Chad M. Warren, Adam R. Wende, Mariam Farjah, E. Dale Abel, R. John Solaro, E. Douglas Lewandowski,