| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10953952 | Journal of Molecular and Cellular Cardiology | 2011 | 10 Pages |
Abstract
⺠Stem cell secreted soluble factors improve overall cardiac function in the damaged myocardium. ⺠Healing processes include protection, neovascularization, differentiation, and remodeling. ⺠Adult stem cells that mediate cytoprotective effects include MSCs, BM-MNCs, EPCs and CPCs. ⺠Stem cell mediated paracrine effects can be enhanced by ex vivo and genetic modification. ⺠Though challenges remain, paracrine factor remains a promising therapy for cardiac repair.
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Authors
Maria Mirotsou, Tilanthi M. Jayawardena, Jeffrey Schmeckpeper, Massimiliano Gnecchi, Victor J. Dzau,