| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10953974 | Journal of Molecular and Cellular Cardiology | 2011 | 10 Pages |
Abstract
⺠Human embryonic stem cell-derived cardiomyocytes increase in size. ⺠Their growth is stimulated by classical physiological and pathological hypertrophic agents. ⺠A number of hypertrophic pathways act in this process, including p38-MAPK, calcineurin, FKBP, mTOR, HDAC II, ERK, JNK, and CAMK II. ⺠The regulation of cell growth and cell cycle progression are separable processes. ⺠The development of the cells can be a tool for the cardiac researcher or pharmaceutical industry.
Keywords
PKGERKFKBPCAMK IImTORGSK3hESC-CMANFbFGFMEFRyR2Jnkc-Jun N-terminal kinasesCa2+/Calmodulin-dependent kinase IIhESCMOIHumanembryoid bodymyosin heavy chainshuman embryonic stem cellsEmbryonic stem cellsatrial natriuretic factorCardiomyocytesMHCmouse embryonic fibroblastmammalian target of rapamycinhistone deacetylaseHypertrophyFK506 binding proteinprotein kinasesprotein kinase Gp38 mitogen-activated protein kinasemultiplicity of infectionextracellular signal-regulated kinasesglycogen synthase kinase 3
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Cell Biology
Authors
Gábor Földes, Maxime Mioulane, Jamie S. Wright, Alexander Q. Liu, Pavel Novak, Béla Merkely, Julia Gorelik, Michael D. Schneider, Nadire N. Ali, Sian E. Harding,