Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10953974 | Journal of Molecular and Cellular Cardiology | 2011 | 10 Pages |
Abstract
⺠Human embryonic stem cell-derived cardiomyocytes increase in size. ⺠Their growth is stimulated by classical physiological and pathological hypertrophic agents. ⺠A number of hypertrophic pathways act in this process, including p38-MAPK, calcineurin, FKBP, mTOR, HDAC II, ERK, JNK, and CAMK II. ⺠The regulation of cell growth and cell cycle progression are separable processes. ⺠The development of the cells can be a tool for the cardiac researcher or pharmaceutical industry.
Keywords
PKGERKFKBPCAMK IImTORGSK3hESC-CMANFbFGFMEFRyR2Jnkc-Jun N-terminal kinasesCa2+/Calmodulin-dependent kinase IIhESCMOIHumanembryoid bodymyosin heavy chainshuman embryonic stem cellsEmbryonic stem cellsatrial natriuretic factorCardiomyocytesMHCmouse embryonic fibroblastmammalian target of rapamycinhistone deacetylaseHypertrophyFK506 binding proteinprotein kinasesprotein kinase Gp38 mitogen-activated protein kinasemultiplicity of infectionextracellular signal-regulated kinasesglycogen synthase kinase 3
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Authors
Gábor Földes, Maxime Mioulane, Jamie S. Wright, Alexander Q. Liu, Pavel Novak, Béla Merkely, Julia Gorelik, Michael D. Schneider, Nadire N. Ali, Sian E. Harding,