Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10953994 | Journal of Molecular and Cellular Cardiology | 2010 | 10 Pages |
Abstract
⺠ROCK1 deletion abolished peripartum mortality, prevented the development of heart failure, and inhibited cardiomycoyte apoptosis while preserving cardiomyocyte hypertrophy in the peripartum Gαq mice. ⺠ROCK1 deficiency improved survival, inhibited cardiomyocyte apoptosis, and preserved LV dimension and function in old Gαq mice at 12 months. ⺠Transgenic overexpression of ROCK1 increased cardiomyocyte apoptosis and accelerated hypertrophic decompensation in Gαq hearts in the absence of pregnancy stress. ⺠The present study demonstrated the long-term beneficial effects of ROCK1 deficiency in hypertrophic decompensation.
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Authors
Jianjian Shi, Yi-Wei Zhang, Yu Yang, Lumin Zhang, Lei Wei,