Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10953997 | Journal of Molecular and Cellular Cardiology | 2010 | 10 Pages |
Abstract
âºThe miR-144/451 cluster is directly regulated by cardiac transcription factor GATA-4. âºIncreased levels of miR-144 and miR-451 protect adult cardiomyocytes against simulated ischemia/reperfusion-induced cell death, and overexpression of miR-144/451 reveals additive effects on cardioprotection. âºBoth miR-144 and miR-451 target CUGBP2, an RNA-binding protein, which interacts with COX-2 3â²UTR and inhibits its mRNA translation. âºCOX-2 is upregulated in miR-144-, miR-451-, and miR-144/451-overexpressing cardiomyocytes. âºInhibition of COX-2 partially abrogates miR-144/451-mediated cardioprotection.
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Authors
Xiaowei Zhang, Xiaohong Wang, Hongyan Zhu, Cheng Zhu, Yigang Wang, William T. Pu, Anil G. Jegga, Guo-Chang Fan,