| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10954031 | Journal of Molecular and Cellular Cardiology | 2011 | 9 Pages |
Abstract
⺠NAD(P)H actively produces superoxide and hydrogen peroxide. ⺠Nox2 mediates cardiac remodeling and angiotensin II-induced cardiac hypertrophy. ⺠Nox4 is a major source of mitochondrial oxidative stress in failing hearts. ⺠Nox4 induces apoptosis and cardiac dysfunction in response to pressure overload. ⺠Nox4 acts as an oxygen sensor and mediates the adaptive response to hypoxia.
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Authors
Yasuhiro Maejima, Junya Kuroda, Shouji Matsushima, Tetsuro Ago, Junichi Sadoshima,