| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10954034 | Journal of Molecular and Cellular Cardiology | 2011 | 9 Pages |
Abstract
âºA novel T618I mutation in the KCNH2 gene underlies the SQT1. âºSteady current of the mutant HERG channels is 6-fold greater than WT. âºThe voltage dependence of inactivation is shifted in the positive direction. âºQuinidine and sotalol effectively inhibit steady currents of mutant channels.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Cell Biology
Authors
Yaxun Sun, Xiao-Qing Quan, Samantha Fromme, Robert H. Cox, Ping Zhang, Li Zhang, Donglin Guo, Jihong Guo, Chinmay Patel, Peter R. Kowey, Gan-Xin Yan,