Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10954035 | Journal of Molecular and Cellular Cardiology | 2011 | 9 Pages |
Abstract
⺠Contractility is less depressed by acidosis in cells and papillary muscles expressing the FHC-linked Tm-E180G mutation. ⺠Myofilament Ca2+ sensitivity is increased in skinned fibers from mice expressing mutated Tm both at normal and acidic pH. ⺠The smaller depression in contractility is not due to altered Tm phosphorylation or differences in intracellular pH.
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Authors
Katherine A. Sheehan, Grace M. Arteaga, Aaron C. Hinken, Fernando A. Dias, Cibele Ribeiro, David F. Wieczorek, R. John Solaro, Beata M. Wolska,