Article ID Journal Published Year Pages File Type
10954035 Journal of Molecular and Cellular Cardiology 2011 9 Pages PDF
Abstract
► Contractility is less depressed by acidosis in cells and papillary muscles expressing the FHC-linked Tm-E180G mutation. ► Myofilament Ca2+ sensitivity is increased in skinned fibers from mice expressing mutated Tm both at normal and acidic pH. ► The smaller depression in contractility is not due to altered Tm phosphorylation or differences in intracellular pH.
Related Topics
Life Sciences Biochemistry, Genetics and Molecular Biology Cell Biology
Authors
, , , , , , , ,