| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10954040 | Journal of Molecular and Cellular Cardiology | 2011 | 13 Pages |
Abstract
⺠Left ventricular (LV) responsiveness to β-adrenergic receptor stimulation is blunted in pigs with a recent myocardial infarction (MI). ⺠We studied if myofilament dysfunction underlies poor response to β-adrenergic activation post-MI. ⺠Myofilament responsiveness to dobutamine is significantly enhanced in MI compared to sham and may involve activation of Ca2+-dependent calmodulin kinase II.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Cell Biology
Authors
Nicky M. Boontje, Daphne Merkus, Ruud Zaremba, Amanda Versteilen, Monique C. de Waard, Giulia Mearini, Vincent J. de Beer, Lucie Carrier, Lori A. Walker, Hans W.M. Niessen, Dobromir Dobrev, Ger J.M. Stienen, Dirk J. Duncker, Jolanda van der Velden,