| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10954044 | Journal of Molecular and Cellular Cardiology | 2011 | 11 Pages |
Abstract
â¶iNOS is upregulated in the diabetic heart by oxidative stress. â¶Oxidative stress induces iNOS uncoupling by depleting BH4. â¶iNOS uncoupling produces more superoxide and causes oxidative/nitrosative stress. â¶Replenishment with BH4 promotes recoupling of iNOS and increases bioavailable NO. â¶Increased NO confers tolerance to I/R injury through protein S-nitrosylation.
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Authors
Toru Okazaki, Hajime Otani, Takayuki Shimazu, Kei Yoshioka, Masanori Fujita, Tayo Katano, Seiji Ito, Toshiji Iwasaka,