| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10954045 | Journal of Molecular and Cellular Cardiology | 2011 | 7 Pages |
Abstract
⺠Caveolin-1 gene transfer interferes with the angiotensin II-induced EGF receptor transactivation cascade including ADAM17 activation. ⺠Caveolin-1 gene transfer inhibited angiotensin II-induced hypertrophy and migration of vascular smooth muscle cells. ⺠ADAM17 colocalizes with Cav1 in the lipid raft fractions. ⺠A disruption of the lipid raft structure leads to HB-EGF shedding and EGF receptor transactivation.
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Authors
Akira Takaguri, Heigoro Shirai, Keita Kimura, Akinari Hinoki, Kunie Eguchi, MaryEllen Carlile-Klusacek, Baohua Yang, Victor Rizzo, Satoru Eguchi,