Inhibition of leukotriene C4 action reduces oxidative stress and apoptosis in cardiomyocytes and impedes remodeling after myocardial injury

► Inhibition of LTC4 action via MRP1 reduced oxidative stress and apoptosis in vitro. ► MRP1-/--mice displayed better cardiac function after cardiac injury. ► Serum LTC4 concentration were reduced in MRP1-/--mice after cardiac injury. ► After cardiac injury cellular apoptosis was reduced in myocardium of MRP1-/--mice. ► Inhibition of LTC4 action provided beneficial cardiac effects in WT-mice. ► MRP1- and Cys-LT1-receptor-blockade may provide targets in ischemic heart disease.