| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10954060 | Journal of Molecular and Cellular Cardiology | 2011 | 9 Pages |
Abstract
âºWe found that myocardial SVV was up-regulated following I/R, possibly serving as a self-protective mechanism. âºOur data showed that treatment with insulin during reperfusion significantly increased myocardial SVV expression through a PI3K/Akt- and mTOR-dependent mechanism. âºRNAi-mediated SVV knockdown facilitated I/R-induced cardiomyocyte apoptosis whereas SVV overexpression reduced SI/R-induced cardiomyocytes from apoptosis. âºMost importantly, SVV knockdown significantly blunted an insulin-induced anti-apoptotic effect.âºOur study demonstrates that SVV is a novel player in insulin-induced cardioprotection in MI/R.
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Authors
Rui Si, Ling Tao, Hai F. Zhang, Qiu J. Yu, Rui Zhang, An L. Lv, Ning Zhou, Feng Cao, Wen Y. Guo, Jun Ren, Hai C. Wang, Feng Gao,