Article ID Journal Published Year Pages File Type
10954066 Journal of Molecular and Cellular Cardiology 2011 11 Pages PDF
Abstract
►Inherent PKA activity drives basal Ca2+ cycling in EC cell-derived cardiac cells. ►L-type Ca2+ current synchronizes phases of local Ca2+ oscillators. ►Synchronized diastolic Ca2+ release activates Na+/Ca2+ exchanger current. ►Diastolic Na+/Ca2+ exchanger current strongly contributes cell automaticity. ►Rhythmic cell automaticity requires coupling of electrophysiology and Ca2+ cycling.
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