| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10954068 | Journal of Molecular and Cellular Cardiology | 2011 | 12 Pages |
Abstract
⺠PKA is required but not sufficient for the anti-mitogenic effects of cAMP in VSMC. ⺠cAMP-induced smooth muscle cell growth arrest is Epac-dependent but Rap1-independent. ⺠PKA and Epac synergise to inhibit smooth muscle cell proliferation. ⺠cAMP inhibits ERK and JNK phosphorylation in a PKA- and Epac-dependent manner. ⺠cAMP-induced stellate morphology of SMC requires PKA and Epac.
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Authors
Richard C. Hewer, Graciela B. Sala-Newby, Yih-Jer Wu, Andrew C. Newby, Mark Bond,