| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10954072 | Journal of Molecular and Cellular Cardiology | 2011 | 9 Pages |
Abstract
⺠Ang II induces early afterdepolarizations (EADs) and triggered activities in rabbit myocytes. ⺠The NADPH oxidase-ROS-calmodulin kinase II (CaMKII) pathway is involved. ⺠The Ang II-induced EADs are caused by the activation of both ICa,L and late INa mediated by CaMKII. ⺠These results support a link between renin-angiotensin system and cardiac arrhythmias.
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Authors
Zhenghang Zhao, Nadezhda Fefelova, Mayilvahanan Shanmugam, Peter Bishara, Gopal J. Babu, Lai-Hua Xie,