Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10954076 | Journal of Molecular and Cellular Cardiology | 2011 | 10 Pages |
Abstract
âºCooperative cardiac thin filament activation depends on cTnC Ca2+ binding kinetics. âºcTnC Ca2+ dissociation rate (koff) affects acto-myosin binding but not cycling. âºAltering koff affects Ca2+ sensitivity of isometric tension development. âºIncreasing koff can decrease the rate of contractile activation. âºDecreasing koff can increase the duration of isometric relaxation.
Keywords
KTRcTNTcTncTnIBDMkoffdATPMOPStmaxGAPPFAPPsTnCDTTpCa50skeletal troponin C2,3-Butanedione monoximePCAContractioncTnCanalysis of varianceANOVATroponinTroponin Ccardiac troponin Ccardiac troponin TCardiac troponinRelaxationdithiothreitolHill coefficientSarcomere lengthCardiac muscleinorganic phosphatecardiac troponin Iinhibition constantkonwild typekact
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Authors
Kareen L. Kreutziger, Nicoletta Piroddi, Jonathan T. McMichael, Chiara Tesi, Corrado Poggesi, Michael Regnier,