| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10954080 | Journal of Molecular and Cellular Cardiology | 2011 | 11 Pages |
Abstract
⺠Fibronectin (FN) acts via α5β1 integrin to increase force production in myocardium. ⺠The force enhanced by FN relates to an increase in intracellular Ca2+ concentration. ⺠FN increases L-type Ca2+ channel currents in cardiomyocytes. ⺠FN-treated myocardium exhibits an increase in myofilament Ca2+ sensitivity. ⺠FN enhances contractility via PKA activation and phosphorylation of phospholamban.
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Authors
Xin Wu, Sanjukta Chakraborty, Cristine L. Heaps, Michael J. Davis, Gerald A. Meininger, Mariappan Muthuchamy,