Article ID Journal Published Year Pages File Type
10954085 Journal of Molecular and Cellular Cardiology 2011 9 Pages PDF
Abstract
► Immune dysregulation causes myocardial fibrosis and diastolic dysfunction in aging mice. ► Diastolic dysfunction is associated with an increased infiltration of CD45+ fibroblasts. ► Progressive fibrosis is accompanied by elevated mRNA level for MCP-1 and IL-13. ► In vitro studies demonstrate that IL-13 enhances monocyte to fibroblast transformation.
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Life Sciences Biochemistry, Genetics and Molecular Biology Cell Biology
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Immune-inflammatory dysregulation modulates the incidence of progressive fibrosis and diastolic stiffness in the aging heart
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