Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10954090 | Journal of Molecular and Cellular Cardiology | 2010 | 10 Pages |
Abstract
Increased myofilament Ca2+ sensitivity is a common attribute of many inherited and acquired cardiomyopathies that are associated with cardiac arrhythmias. Accumulating evidence supports the concept that increased myofilament Ca2+ sensitivity is an independent risk factor for arrhythmias. This review describes and discusses potential underlying molecular and cellular mechanisms how myofilament Ca2+ sensitivity affects cardiac excitation and leads to the generation of arrhythmias. Emphasized are downstream effects of increased myofilament Ca2+ sensitivity: altered Ca2+ buffering/handling, impaired energy metabolism and increased mechanical stretch, and how they may contribute to arrhythmogenesis.
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Authors
Sabine Huke, Björn C. Knollmann,