Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10954143 | Journal of Molecular and Cellular Cardiology | 2010 | 14 Pages |
Abstract
Heart failure affects nearly 6Â million Americans, with a half-million new cases emerging each year. Whereas up to 50% of heart failure patients die of arrhythmia, the diverse mechanisms underlying heart failure-associated arrhythmia are poorly understood. As a consequence, effectiveness of antiarrhythmic pharmacotherapy remains elusive. Here, we review recent advances in our understanding of heart failure-associated molecular events impacting the electrical function of the myocardium. We approach this from an anatomical standpoint, summarizing recent insights gleaned from pre-clinical models and discussing their relevance to human heart failure.
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Authors
Yanggan Wang, Joseph A. Hill,