Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10954354 | Journal of Molecular and Cellular Cardiology | 2005 | 8 Pages |
Abstract
T3 mediates an early stimulation of enzymes containing mtDNA encoded subunits (e.g. complex IV and V) in contrast to a different regulatory pattern for the entirely nuclear-encoded enzymes (e.g. CS and complex II). T3-regulation was similar in both neonatal and young adult cardiomyocytes (ARCM) but absent in the senescent cardiomyocytes. This model offer an opportunity to study the rapid timing of events involved in myocardial cell signaling, bioenergetics and growth dynamics in a timeframe not available with whole animal studies.
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Authors
Michael J. Goldenthal, Radha Ananthakrishnan, José MarÃn-GarcÃa,