Polyribosome and ribonucleoprotein complex redistribution of mRNA induced by GnRH involves both EIF2AK3 and MAPK signaling

- GnRH treatment of gonadotrope-derived cells causes remodeling of ribosome content.
- Enrichment of mRNA in non-translating RNP complexes is associated with activation of EIF2AK3/PERK.
- Enrichment of mRNA in active polyribosome complexes is associated with activation of ERK.
- Dusp1 mRNA, a factor important for the regulatory feedback of ERK, is enriched in polyribosomes.
- The mRNA binding protein ELAV1 binds the DUSP1 3′UTR and confers resistance to translational suppression induced by GNRH.