| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10956137 | Molecular and Cellular Endocrinology | 2014 | 10 Pages |
Abstract
- COUP-TFII inhibits TNFα-activated NFκB transactivation in tamoxifen-resistant LCC9 cells.
- COUP-TFII inhibits endogenous NFκB-regulated genes in breast cancer cells.
- COUP-TFII and NFκB expression are inversely correlated in breast tumors.
- COUP-TFII inhibits RelB, RelA, and p50 NFκB -DNA binding.
- Endogenous COUP-TFII interacts with NFκB1 p50 and RelB in TNFα-treated MCF-7 cells.
Keywords
4-OHTTNFαSERMqPCRIL6ICAM1SERDERα4-hydroxytamoxifenTAMtamoxifenAntiestrogensresponse elementTranscription factorstumor necrosis factornuclear factor κBSelective estrogen receptor modulatorDrug resistanceIntercellular adhesion molecule 1quantitative real-time PCRCOUP-TFIIEstrogen receptornuclear receptors
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Authors
Lacey M. Litchfield, Savitri N. Appana, Susmita Datta, Carolyn M. Klinge,