Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10956143 | Molecular and Cellular Endocrinology | 2014 | 11 Pages |
Abstract
Prolactin (PRL) is a polypeptide hormone with a wide range of physiological functions, and is critical for female reproduction. PRL exerts its action by binding to membrane bound receptor isoforms broadly classified as the long form and the short form receptors. Both receptor isoforms are highly expressed in the ovary as well as in the uterus. Although signaling through the long form is believed to be more predominant, it remains unclear whether activation of this isoform alone is sufficient to support reproductive functions or whether both types of receptor are required. The generation of transgenic mice selectively expressing either the short or the long form of PRL receptor has provided insight into the differential signaling mechanisms and physiological functions of these receptors. This review describes the essential finding that both long and short receptor isoforms are crucial for ovarian functions and female fertility, and highlights novel mechanisms of action for these receptors.
Keywords
PRL20α-HSDIGFBP1PRLRJanus Kinase 2galactose-1-phosphate uridylyltransferaseJAK2GALTα2MMAPKAlpha 2-MacroglobulinSTATFluorescence resonance energy transferFRETOvaryReproductioncorpus luteumEndothelial cellsVascular endothelial growth factorVascular Endothelial Growth Factor (VEGF)Placental lactogenSignal transducer and activator of transcriptionGrowth hormoneInsulin-like growth factor binding protein 1mitogen activated protein kinaseProlactinprolactin receptor
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Authors
Y. Sangeeta Devi, Julia Halperin,