Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10956156 | Molecular and Cellular Endocrinology | 2014 | 12 Pages |
Abstract
The recent growth of interest in developmental programming of physiological systems has generally focused on the cardiovascular system (especially hypertension) and predisposition to metabolic dysfunction (mainly obesity and diabetes). However, it is now clear that the full range of altered offspring phenotypes includes impaired reproductive function. In rats, sheep and nonhuman primates, reproductive capacity is altered by challenges experienced during critical periods of development. This review will examine available experimental evidence across commonly studied experimental species for developmental programming of female and male reproductive function throughout an individual's life-course. It is necessary to consider events that occur during fetal development, early neonatal life and prior to and during puberty, during active reproductive life and aging as reproductive performance declines.
Keywords
IUGRDHTGnRHACTH11β-hsd211β-Hydroxysteroid dehydrogenase type 2P450sccDESSex steroidsAMHfetalDiethylstilbestrolDihydrotestosteroneStarintrauterine growth restrictionHPAneonataladrenocorticotropic hormoneAntimüllerian hormoneGonadotropin-releasing hormonefollicle-stimulating hormoneluteinizing hormoneFSHhypothalamic–pituitary–adrenalsteroid acute regulatory proteinMaternal obesityMaternal undernutritionGlucocorticoidsAndrogen ReceptorEstrogen receptorProgesterone receptorglucocorticoid receptor
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Authors
Elena Zambrano, Carolina Guzmán, Guadalupe L. RodrÃguez-González, Marta Durand-Carbajal, Peter W. Nathanielsz,