| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10956208 | Molecular and Cellular Endocrinology | 2013 | 13 Pages |
Abstract
⺠Testosterone loss suppresses myofibrillar protein synthesis and Akt/mTORC1 signaling. ⺠Testosterone loss activates muscle FoxO3a and its transcriptional targets. ⺠Androgen administration restores Akt/mTORC1/FoxO3a signaling in castrated mice. ⺠In C2C12 myotubes, testosterone can activate mTORC1 independent of Akt activation. ⺠24 h T withdrawal amplifies the activation of Akt/mTORC1 after acute T stimulation.
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Authors
James P. White, Song Gao, Melissa J. Puppa, Shuichi Sato, Stephen L. Welle, James A. Carson,