| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10956214 | Molecular and Cellular Endocrinology | 2013 | 10 Pages |
Abstract
⺠Curcumin ameliorates diabetic nephropathy in the STZ-induced diabetic rats. ⺠Curcumin inhibits the SphK1-S1P signaling pathway in the diabetic rat kidneys. ⺠Curcumin inhibits the SphK1-S1P signaling pathway in GMCs exposed to HG. ⺠Curcumin inhibits SphK1-S1P-mediated FN and TGF-β1 overproduction. ⺠The effect of curcumin may be closely related to the inhibition of AP-1 activity.
Keywords
ECMS1PSTZTGF-β1CURFBGGMCsAP-1GBMSphKLC-MS/MSsiRNAAlbuminuriaStreptozocinSprague DawleySphingosine kinaseSphingosine kinase 1sphingosine 1-phosphateperiodic acid-SchiffTransforming growth factor-beta 1small interference RNABUNglomerular mesangial cellsAgeliquid chromatography tandem-mass spectrometryglomerular basement membraneFibronectinfasting blood glucoseExtracellular matrixDiabetic nephropathyPASblood urea nitrogenactivator protein 1advanced glycation end productserum creatinineCurcuminhigh glucosenormal glucose
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Authors
Juan Huang, Kaipeng Huang, Tian Lan, Xi Xie, Xiaoyan Shen, Peiqing Liu, Heqing Huang,