| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10956217 | Molecular and Cellular Endocrinology | 2013 | 10 Pages |
Abstract
⺠We study CsA, tacrolimus and rapamycin effects on human adipose tissue lipid metabolism. ⺠Immunosuppressive agents enhance lipolysis and inhibit lipid storage. ⺠Effects on lipolysis are associated with increased HSL phosphorylation. ⺠Changes of lipogenic genes are observed in adipose tissue treated with the drugs. ⺠Effects on adipose tissue may contribute to dyslipidemia associated with therapy.
Keywords
mTORC1/2pKap70S6KCGI-58PPARγDGAT1HSLmTORFFACNIFASSREBP1AP2PKBLPLMAPKp70 ribosomal S6 kinaseAdipocytesAtglfatty acid synthaseFree fatty acidsCSATacrolimusnew-onset diabetes after transplantationLipid storageRapamycincyclosporin Abody mass indexBMIImmunosuppressive agentadipose triacylglycerol lipasehormone-sensitive lipaseLipoprotein lipaseLipolysisLow-density lipoproteinLDLcalcineurin inhibitorNODATmammalian target of rapamycinfatty acid binding protein 4sterol regulatory element-binding protein 1protein kinase Aprotein kinase Bmitogen-activated protein kinaseperoxisome proliferator-activated receptor γ
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Authors
Maria J. Pereira, Jenny Palming, Magnus Rizell, Manuel Aureliano, Eugénia Carvalho, Maria K. Svensson, Jan W. Eriksson,