| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10956221 | Molecular and Cellular Endocrinology | 2013 | 6 Pages |
Abstract
⺠Ghrelin requires GHS-R1a for its effect on hypothalamic, liver and adipose tissue AMPK activity. ⺠An intact ghrelin signalling pathway is required for the effects of cannabinoids on AMPK activity. ⺠Ghrelin and cannabinoids stimulate hypothalamic but inhibit liver and visceral fat AMPK. ⺠Treatment with HU210 at 20 ng/g significantly inhibited inguinal fat AMPK activity. ⺠We report the loss of inhibitory effects of ghrelin on liver AMPK activity in GHS-R1a KO mice.
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Authors
Chung Thong Lim, Blerina Kola, Daniel Feltrin, Diego Perez-Tilve, Matthias H. Tschöp, Ashley B. Grossman, Márta Korbonits,