Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10956229 | Molecular and Cellular Endocrinology | 2012 | 8 Pages |
Abstract
⺠We analyzed the ability of celecoxib to sensitize TT cell line to vinorelbine as compared to doxorubicin. ⺠Celecoxib induced apoptosis and decreased drug efflux in TT cells. ⺠TT cells were 10-fold more resistant to doxorubicin than to vinorelbine. ⺠The association of celecoxib with vinorelbine, but not with doxorubicin, reduced cell viability and increased apoptosis.
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Authors
A. Vivaldi, R. Ciampi, A. Tacito, E. Molinaro, L. Agate, V. Bottici, A. Pinchera, P. Collecchi, R. Elisei,