| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10956241 | Molecular and Cellular Endocrinology | 2012 | 9 Pages |
Abstract
⺠The vitamin D3 catabolizing enzyme, CYP24, is aberrantly expressed in lung cancer. ⺠The effect of CYP24 inhibitor CTA091 on vitamin D3 (1,25D3) activity was examined. ⺠CTA091 significantly increased effects of 1,25D3 on endogenous gene expression. ⺠Expression profiling revealed cell cycle as a 1,25D3 target in lung cancer cells. ⺠Inhibitory effects of 1,25D3 on cell cycle and cell growth were reinforced by CTA091.
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Authors
Qiuhong Zhang, Beatriz Kanterewicz, Shama Buch, Martin Petkovich, Robert Parise, Jan Beumer, Yan Lin, Brenda Diergaarde, Pamela A. Hershberger,