| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10956251 | Molecular and Cellular Endocrinology | 2012 | 9 Pages |
Abstract
⺠Fibrosis of the airways is an important aspect of asthma pathology. ⺠Fibrotic remodeling is regulated by asthma associated genes, including relaxin. ⺠New therapies may target pathways (e.g. TGFβ-Smad pathway) regulated by relaxin.
Keywords
OVAReticular basement membraneEMTUp-Smad2RXFP1RelaxinASMECMTGFβAADMMPAsthmaOvalbuminAirway remodelingAllergic airways diseasetransforming growth factor-βTherapyTIMPRBMAirway smooth muscleFibrosisExtracellular matrixmatrix metalloproteinaseTissue inhibitors of metalloproteinaseglucocorticoid receptor
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Authors
Simon G. Royce, Victor Cheng, Chrishan S. Samuel, Mimi L.K. Tang,