| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10956259 | Molecular and Cellular Endocrinology | 2012 | 15 Pages |
Abstract
⺠The CXCL12/CXCR4 axis functionally activates the AR in the absence of androgen. ⺠CXCL12/CXCR4 promotes nuclear accumulation of the AR and SRC-1 co-regulator. ⺠CXCL12/CXCR4 stimulates AR-regulated gene transcription and cellular proliferation. ⺠CXCL12/CXCR4 activates AR and SRC-1 viaPI3K- and MAPK-mediated phosphorylation. ⺠CXCL12/CXCR4-mediated AR activation may provide a new therapeutic target.
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Authors
Sathish Kasina, Jill A. Macoska,