| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10956260 | Molecular and Cellular Endocrinology | 2012 | 5 Pages |
Abstract
⺠Lin28 proteins regulate micro RNAs and are implicated in germ cell development. ⺠We assessed LIN28A and LIN28B in the early human ovary and testis. ⺠Expression of LIN28A increases in the developing ovary between 6 and 9 weeks conception. ⺠Expression of LIN28B was lower and did not change. ⺠Alterations in LIN28A were not found in women with primary ovarian insufficiency.
Keywords
PBSHDBRLIN28ALin28bPGCCarnegie stageprimary ovarian insufficiency (POI)POITBSTDAPIqRT-PCRGAPDHWPC4′,6-diamidino-2-phenylindolGerm cellPrimordial germ cellPhosphate-buffered salineMicroRNAMiRNAPrimary ovarian insufficiencypremature ovarian failure (POF)follicle-stimulating hormoneFSHquantitative real-time PCRglyceraldehyde-3-phosphate dehydrogenase
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Authors
Ranna El-Khairi, Rahul Parnaik, Andrew J. Duncan, Lin Lin, Dianne Gerrelli, Mehul T. Dattani, Gerard S. Conway, John C. Achermann,