| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10956263 | Molecular and Cellular Endocrinology | 2012 | 10 Pages |
Abstract
⺠DAG inhibited skeletal muscle proteolysis in burned rats. ⺠DAG reversed the anti-anabolic and catabolic effects of TNF and IFN on myotubes. ⺠DAG activated the PI3K/Akt pathway. ⺠DAG inhibited atrophy signals, phospho-NF-κB, MAFbx and MuRF1. ⺠The latter pathways may mediate the anti-catabolic and anabolic effects of DAG.
Keywords
IGF-IMAFbxTBSAMuRF-1NF-κBGSK3βdes-acyl ghrelinGHS-R1aNPYgrowth hormone secretagogue receptor 1AmTORIL-6GHRP-2PI3KAtrophyinterleukin-6tumor necrosis factor-αDAGTotal body surface areaBurn injuryinsulin-like growth factor 1TNF-αnuclear factor kappa Bphosphatidylinositol-3 kinaseSignaling pathwaysmammalian target of rapamycinHypertrophyglycogen synthase kinase-3 betaNeuropeptide Y
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Authors
Sulaiman Sheriff, Nijiati Kadeer, Rashika Joshi, Lou Ann Friend, J. Howard James, Ambikaipakan Balasubramaniam,