| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10956267 | Molecular and Cellular Endocrinology | 2012 | 11 Pages |
Abstract
⺠Use of radioligand dissociation assay to identify novel allosteric lutropin receptor modulators. ⺠A second allosteric binding pocket that provides extended opportunities for drug discovery. ⺠Similarities between allosteric and orthosteric binding sites of different GPCRs.
Keywords
PBSA2ARGPCRA3R7-TMECLLMWBSAcAMPG protein-coupled receptorsAdenosine A3 receptorbovine serum albuminHCGChoChinese Hamster Ovaryextracellular loopstandard error of the meanPhosphate-buffered salineSEMAllosteric modulationseven transmembraneRecombinant luteinizing hormonelow molecular weighthuman chorionic gonadotropinAdenosine A2A receptorLutropin receptorGlycoprotein hormone receptorsLuteinizing hormone receptorG protein-coupled receptor
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Authors
Laura H. Heitman, Gunnar Kleinau, Johannes Brussee, Gerd Krause, Adriaan P. IJzerman,