| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10956279 | Molecular and Cellular Endocrinology | 2012 | 9 Pages |
Abstract
⺠Low LH enhanced the productions of androstenedione (A4) and progesterone (P4), and expressions of CYP17 and StAR mRNA in theca cells. ⺠The binding of SF-1 to the CYP17 and StAR promoter regions increased in theca cells treated with low LH. ⺠Low LH enhanced the binding of GATA-6, but not of GATA-4, to the CYP17 promoter region. ⺠LH regulates the production of A4 and P4 by switching of transcription factors in theca cells.
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Authors
Chiaki Murayama, Hitoshi Miyazaki, Akio Miyamoto, Takashi Shimizu,