Protein phosphorylation involved in the gene expression of the hydrogen sulphide producing enzyme cystathionine Î³-lyase in the pancreatic Î²-cell

Article ID	Journal	Published Year	Pages	File Type
10956282	Molecular and Cellular Endocrinology	2012	8 Pages	PDF

Abstract

âº CSE is an inducible enzyme that produces the gasomessenger H2S in pancreatic Î²-cells. âº Induction of CSE is dependent on an increase in intracellular Ca2+. âº Protein phosphorylation by CaMK II and ERK is involved in CSE expression. âº Two ERK-phosphorylatable transcription factors, Sp1 and Elk1, regulate CSE expression.

Keywords

ELK1 CBS NO synthase CaMK PPG dl-propargylglycine iNOS NOS ERK CAMK II CAT T-TBS CSE 3-MST H2S VDCC ATP-sensitive K+-channels FBS NSAIDS cystathionine γ-lyase MAPK inducible NOS Small interfering RNA ROS siRNA Sp1 Pancreatic islets Non-steroidal anti-inflammatory drugs fetal bovine serum Hydrogen sulphide cysteine aminotransferase cystathionine β-synthase endoplasmic reticulum Specificity protein 1 carbon monoxide Nitric oxide heme oxygenase mitogen-activated protein kinase Ca2+/calmodulin-dependent protein kinase Extracellular signal-regulated protein kinase Voltage-dependent Ca2+ channels KATP channels Reactive oxygen species