Bone morphogenetic protein-3b (BMP-3b) inhibits osteoblast differentiation via Smad2/3 pathway by counteracting Smad1/5/8 signaling

Article ID	Journal	Published Year	Pages	File Type
10956287	Molecular and Cellular Endocrinology	2012	9 Pages	PDF

Abstract

âº BMP-3b stimulates Smad2/3 via the receptor combination of ALK-4/ActRIIAin C2C12 cells. âº BMP-3b suppresses osteoblastic marker expression induced by BMP-2, -4, -6 and -7. âº BMP-2 suppresses BMP-3b-induced Smad2/3 signaling by competing Smad4. âº BMP-3b inhibits osteoblast differentiation, in which BMP-3b and -2 are mutually antagonistic.

Keywords

ECD RUNX2 GDF BMPR TGF AmhrII SMAD TβRII ALK Osteoblast AMH transforming growth factor extracellular domain C2C12 cells Growth differentiation factor Runt-related transcription factor 2 BMP Anti-Müllerian hormone Bone morphogenetic protein bone morphogenetic protein (BMP)activin receptor-like kinase BMP receptor

Related Topics

Life Sciences Biochemistry, Genetics and Molecular Biology Cell Biology

Preview

Bone morphogenetic protein-3b (BMP-3b) inhibits osteoblast differentiation via Smad2/3 pathway by counteracting Smad1/5/8 signaling

Authors

Yoshinori Matsumoto, Fumio Otsuka, Jun Hino, Tomoko Miyoshi, Mariko Takano, Mikiya Miyazato, Hirofumi Makino, Kenji Kangawa,