Article ID Journal Published Year Pages File Type
10956304 Molecular and Cellular Endocrinology 2012 10 Pages PDF
Abstract
► SRCs interact with and promote NR-mediated transcriptional activation by recruiting co-coactivators to their activation domains. ► SRC-1 and SRC-3 drive tumorigenesis and are particularly overexpressed in breast cancer. ► SRC-1 and SRC-3 negatively correlate with overall and disease-free survival and positively with tamoxifen resistance. ► Tumors may develop resistance to SRMs through overexpression or cell signaling-mediated activation of coactivators, like SRCs. ► Coactivators may promote resistance in NR-dependent and independent cancers making coactivator-specific inhibitors promising candidates.
Related Topics
Life Sciences Biochemistry, Genetics and Molecular Biology Cell Biology
Authors
, ,