Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10956304 | Molecular and Cellular Endocrinology | 2012 | 10 Pages |
Abstract
⺠SRCs interact with and promote NR-mediated transcriptional activation by recruiting co-coactivators to their activation domains. ⺠SRC-1 and SRC-3 drive tumorigenesis and are particularly overexpressed in breast cancer. ⺠SRC-1 and SRC-3 negatively correlate with overall and disease-free survival and positively with tamoxifen resistance. ⺠Tumors may develop resistance to SRMs through overexpression or cell signaling-mediated activation of coactivators, like SRCs. ⺠Coactivators may promote resistance in NR-dependent and independent cancers making coactivator-specific inhibitors promising candidates.
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Authors
Amber B. Johnson, Bert W. O'Malley,