Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10956313 | Molecular and Cellular Endocrinology | 2012 | 7 Pages |
Abstract
⺠Vessel remodelling in early human pregnancy requires trophoblast invasion. ⺠hCG, P4 and E2 are all found at high concentrations at the maternal-foetal interface. ⺠These hormones can control trophoblast movement and thus may regulate remodelling. ⺠We review the effects of these pregnancy hormones on trophoblast function. ⺠A role for these hormones in defective remodelling seen in pre-eclampsia is examined.
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Authors
Jessie Z.-J. Chen, Penelope M. Sheehan, Shaun P. Brennecke, Rosemary J. Keogh,