Phosphodiesterase 5 (PDE5) inhibition, ANP and NO rapidly reduce epididymal duct contractions, but long-term PDE5 inhibition in vivo does not

Article ID	Journal	Published Year	Pages	File Type
10956314	Molecular and Cellular Endocrinology	2012	9 Pages	PDF

Abstract

âº PDE5 localizes to smooth muscle, but not to epithelial cells, of the epididymal duct. âº Increase of cGMP by ANP, NO and PDE5 inhibition reduces epididymal duct contractility. âº PDE5 inhibition is additive to ANP and NO effects. âº PDE5 expression is unaltered in a model of long-term PDE5 inhibition in vivo. âº In this model acute cGMP effects on epididymal duct contractility are conserved.

Keywords

ANP cGMP CNP BNP GC-B GC-A bpm beats per minute cyclic guanosine monophosphate C-type natriuretic peptide Brain-type natriuretic peptide atrial natriuretic peptide

Related Topics

Life Sciences Biochemistry, Genetics and Molecular Biology Cell Biology

Preview

Phosphodiesterase 5 (PDE5) inhibition, ANP and NO rapidly reduce epididymal duct contractions, but long-term PDE5 inhibition in vivo does not

Authors

Andrea Mietens, Sabine Tasch, Caroline Feuerstacke, Gerrit Eichner, Johanna Volkmann, Ralph Theo Schermuly, Friedrich Grimminger, Dieter Müller, Ralf Middendorff,