| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10956318 | Molecular and Cellular Endocrinology | 2012 | 9 Pages |
Abstract
⺠It is unclear whether fat mass increases bone density only by the higher weight. ⺠We investigate the role of adipocytes as an endocrine tissue in this context. ⺠Adipocyte-secreted factors include bFGF. ⺠These factors increase preosteoblast proliferation and OPG/RANKL ratio. ⺠These findings may represent an endocrine effect of adipocytes on osteoblasts.
Keywords
EGFM-CSFOPGPDGFFGFR1PI3KpKaTRAPBMDRANKLbFGFReceptor activator of nuclear factor kappa BsFRPLRPJanus kinaseMAPK/ERK kinaseALPAlkaline phosphataseDkkdickkopfOsteoblastsOsteoprotegerintartrate-resistant acid phosphataseBone mineral densityRankbody mass indexBMIepidermal growth factorplatelet-derived growth factorbasic fibroblast growth factorphosphatidylinositol-3-kinasemacrophage colony-stimulating factorMEKObesitySecreted frizzled-related proteinlow density lipoprotein receptor-related proteinprotein kinase AOsteoporosisJAKcontrol mediumreceptor activator of nuclear factor kappa B ligand
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Authors
Markus C. Kühn, Holger S. Willenberg, Matthias Schott, Claudia Papewalis, Ulla Stumpf, Sascha Flohé, Werner A. Scherbaum, Sven Schinner,