| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10956328 | Molecular and Cellular Endocrinology | 2012 | 10 Pages |
Abstract
⺠Twenty-Hydroxyecdysone (20E) plays a central role in egg development in mosquitoes. ⺠The nuclear receptor E75 is an essential factor in the 20E genetic hierarchy. ⺠We identified distinct roles of E75 isoforms in vitellogenesis of Aedes aegypti. ⺠Heme is required in a high level of E75-mediated expression of 20E-controlled genes. ⺠Heme serves as a sensor of the availability of a protein meal for egg development.
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Authors
Josefa Cruz, Daniel Mane-Padros, Zhen Zou, Alexander S. Raikhel,