Phosphoinositide 3-kinase as a novel functional target for the regulation of the insulin signaling pathway by SIRT1

Article ID	Journal	Published Year	Pages	File Type
10956342	Molecular and Cellular Endocrinology	2011	11 Pages	PDF

Abstract

Our data identify SIRT1 as a positive modulator of insulin signaling in muscle cells through PI3K, and this mechanism appears to be conserved from C. elegans through humans.

Keywords

AMPK IIS Sirtuins PKB PTP1B PGC-1α Insulin/insulin-like signaling HEK293 IRS C. elegans TNFα PI3K AMP-activated protein kinase MAPK PI(4,5)P2 insulin receptor substrate tumor necrosis factor α Resveratrol Aging Insulin signaling Phosphatidylinositol(4,5)bisphosphate phosphoinositide 3-kinase Protein tyrosine phosphatase 1B protein kinase B mitogen activated protein kinase

Related Topics

Life Sciences Biochemistry, Genetics and Molecular Biology Cell Biology

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Phosphoinositide 3-kinase as a novel functional target for the regulation of the insulin signaling pathway by SIRT1

Authors

Sara Fröjdö, Christine Durand, Laurent Molin, Andrew L. Carey, Assam El-Osta, Bronwyn A. Kingwell, Mark A. Febbraio, Florence Solari, Hubert Vidal, Luciano Pirola,