| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10956350 | Molecular and Cellular Endocrinology | 2011 | 6 Pages |
Abstract
The vGPCRs may contribute to the escape of immune surveillance and (constitutively) activate signaling pathways linked to proliferation and inflammation. Some vGPCRs induce activation of autocrine and paracrine signaling, resulting in secretion of growth factors and/or cytokines. As a result, vGPCRs effectively rewire cellular signaling networks. Delineating the cellular signaling networks modulated by these vGPCRs will be crucial for treatment of virus-associated pathologies.
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Authors
Erik Slinger, Ellen Langemeijer, Marco Siderius, Henry F. Vischer, Martine J. Smit,