Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10956356 | Molecular and Cellular Endocrinology | 2011 | 9 Pages |
Abstract
The melanocortin-4 receptor (MC4R) is a prototypical G protein-coupled receptor (GPCR) that plays a considerable role in controlling appetite and energy homeostasis. Signalling initiated by MC4R is orchestrated by multiple agonists, inverse agonism and by interactions with accessory proteins. The exact molecular events translating MC4R signalling into its physiological role, however, are not fully understood. This review is an attempt to summarize new aspects of MC4R signalling in the context of its recently discovered alternative G protein coupling, and to give a perspective on how future research could improve our knowledge about the intertwining molecular mechanisms that are responsible for the regulation of energy homeostasis by the melanocortin system.
Keywords
PTXguanosine 5′-(3-O-thio)triphosphateACTHMahogunin Ring Finger-1ERK-1/2MSHRAMPSMC4RCTXforskolinPI3KPKCPLCFskAgRPPOMCGPCRIRSpKacAMPcyclic 3′,5′-adenosine monophosphateG protein-coupled receptorsBiased agonisminsulin receptor substratepertussis toxincholera toxinendoplasmic reticulumphosphatidylinositol-3-kinasephospholipase CObesityMelanocortinsadrenocorticotropic hormoneAgouti-related proteinprotein kinase AProtein kinase Cproopiomelanocortinextracellular signal-regulated kinasesMelanocortin-4 receptor
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Authors
Andreas Breit, Thomas R.H. Büch, Ingrid Boekhoff, Hans Jürgen Solinski, Ellen Damm, Thomas Gudermann,