| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10956362 | Molecular and Cellular Endocrinology | 2011 | 12 Pages |
Abstract
In this review we describe the state of low-grade inflammation observed in PCOS. In addition, we hypothesize the potential mechanisms responsible for the generation of this inflammatory state and the role played by low-grade inflammation in linking hyperandrogenism and insulin resistance with the metabolic and cardiovascular long-term complications of the syndrome.
Keywords
IL-18MMP9FFAIL-8vWFTRL4RASiNOSPAI-1MCP-1FMDAGEsIMTPDGFET-1NF-κBHIF-1αGSK3IRS-1IL-1TGF-βsE-selectinADMAsICAM-1MMP2IL-6HSLA-FABPIP-10SOCS3ESRMPVPCOSHDLsVCAM-1Akt/Protein kinase BandrogensAkt/PKBFree fatty acidsendothelin-1insulin receptor substrate-1Interleukin-8Interleukin-18interleukin-6interleukin-1Adipose tissuetransforming growth factor-βtumor necrosis factor-αglucose transporter 4asymmetric dimethylarginineFlow-mediated dilatationsuppressor of cytokine signaling 3inducible nitric oxide synthasePolycystic ovary syndromeRenin–angiotensin systemintima media thicknesshypoxia inducible factor-1αPlatelet activating factorVon Willebrand factorVascular endothelial growth factorVascular Endothelial Growth Factor (VEGF)platelet-derived growth factorTNF-αnuclear factor-κBhormone sensitive lipasehigh density lipoproteinlow density lipoproteinLDLmatrix metallopeptidase 2matrix metallopeptidase 9Toll like receptor 4Advanced glycation endproductsRANTESInsulin resistancePlasminogen activator inhibitor-1Soluble intercellular adhesion molecule-1Soluble vascular cell adhesion molecule-1Nitric oxidePAFMonocyte chemotactic protein-1Interferon-inducible protein-10Adipocyte fatty acid-binding proteinCRPGlut-4glycogen synthase kinase 3
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Cell Biology
Authors
Andrea Repaci, Alessandra Gambineri, Renato Pasquali,