| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10956528 | Molecular and Cellular Neuroscience | 2012 | 11 Pages |
Abstract
The results obtained here indicate that MSC-secreted factors induce glial-dependent neuronal survival and trigger an augmented GABAergic transmission in hippocampal cultures, highlighting a new effect by which MSCs could promote CNS repair. Our results suggest that MSCs may be useful in those neurological disorders characterized by an impairment of excitation versus inhibition balance.
Keywords
PBSVGATSynaptogenesisGFAPSYPGDBMSCBDNFBSAAstrocytebovine serum albuminNeurodegenerative diseasesEnzyme-linked immunosorbent assayELISAvesicular GABA transporterminimum essential mediumAraCDIVday in vitroMesenchymal stem cellSynaptophysinGABAergic synapseBrain-derived neurotrophic factorMEMPhosphate-buffered salineNeurotrophinsHippocampal neuronGlial fibrillary acidic protein
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Authors
Mario Mauri, Daniela Lentini, Marta Gravati, Dana Foudah, Gerardo Biella, Barbara Costa, Mauro Toselli, Marco Parenti, Silvia Coco,